Vagifem
Vagifem
Learn what Vagifem is, its benefits and how to use it safely.
Medically reviewed by Dr Zahra Khan
MBBS, MSc (Dist)
Updated on 1st August 2025What is Vagifem?
Vagifem is a low-dose vaginal oestrogen therapy prescribed to treat symptoms of vaginal atrophy, now more commonly referred to as Genitourinary Syndrome of Menopause (GSM). It comes as a small, bullet-shaped pessary (vaginal tablet) that is inserted into the vagina using a disposable applicator.
Each pessary contains 10 micrograms of oestradiol, a type of oestrogen identical to the one naturally produced by the ovaries. Vagifem delivers this hormone directly to the vaginal tissues, helping to restore moisture, elasticity, and a healthy pH, all of which decline after menopause.[1]
Because the treatment is local rather than systemic, only a very small amount of oestrogen enters the bloodstream. This makes Vagifem an effective and low-risk option for many women.
Why use Vagifem?
After the menopause, oestrogen levels fall significantly. This hormonal drop affects the vulva, vagina, bladder, and lower urinary tract. Common symptoms of GSM include:
- Vaginal dryness or irritation
- Discomfort or pain during sex (dyspareunia)
- Itching or burning sensations
- Urinary urgency, frequency, or pain
- Recurrent urinary tract infections (UTIs)
- Reduced vaginal elasticity, thinning skin, or loss of discharge
These symptoms can significantly affect a woman's quality of life. Many women assume they are ‘just part of getting older’ but they are treatable. Importantly, GSM does not always respond to standard systemic HRT, which is why local oestrogen therapy like Vagifem is considered first-line treatment for persistent urogenital symptoms.
How does Vagifem work?
Each Vagifem pessary delivers a precise low dose of oestradiol directly to the vaginal tissues. This:
- Rehydrates and thickens the vaginal lining
- Restores the pH balance, helping maintain healthy microbiota
- Improves blood flow and tissue integrity
- Reduces inflammation, helping alleviate urinary and genital symptoms
Most women begin to feel improvement in vaginal moisture and comfort within 2 to 4 weeks. However, full effects, especially for urinary symptoms it may take up to 12 weeks of consistent use.
Unlike moisturisers or lubricants, Vagifem targets the underlying hormonal cause, offering long-term symptom relief when used regularly.
How to use Vagifem
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Everything you need to know to safely use Vagifem
Benefits of Vagifem
Vagifem is used to treat a range of symptoms associated with vaginal atrophy.
It works directly on the vaginal tissues and is minimally absorbed into the bloodstream, Vagifem is often a suitable option for women who can’t tolerate systemic HRT. Many women find that, beyond physical relief, Vagifem restores confidence and comfort in everyday life.
Vagifem treats the following symptoms:
Frequently asked questions
This page is provided for reference purposes only. Always follow the advice and guidance of your prescribing doctor regarding your medication and prescriptions. Do not make any changes to your medication regimen without consulting your healthcare provider.