Why do I need Gepretix if I’m on oestrogen?

If you still have a womb, oestrogen alone can cause the lining to thicken, increasing the risk of endometrial cancer. Gepretix helps protect against that.

Does Gepretix cause weight gain?

There’s no strong link between Gepretix and weight gain. Any changes are more likely related to the menopause transition, lifestyle, or water retention.

Does it help with sleep?

Many people report better sleep when taking Gepretix at night, likely due to its natural calming effect.

What happens if I take it every day?

Taking it daily is part of the continuous HRT regimen, suitable for postmenopausal women. It helps prevent womb thickening and usually avoids monthly bleeding.

What’s the difference between continuous and cyclical use?

Cyclical use leads to a monthly withdrawal bleed and is used when you’re still having periodsContinuous use aims to be bleed-free and is used once your periods have stopped

Can I take Gepretix without oestrogen?

No. Gepretix does not relieve menopause symptoms on its own. It is taken alongside oestrogen and provides protection for the womb lining.

When should I take it?

At bedtime, on an empty stomach (at least two hours after eating), to enhance absorption and minimise side effects like drowsiness.

Gepretix

Learn what Gepretix is, its benefits and how to use it safely.

Medically reviewed by Dr Zahra Khan

MBBS, MSc (Dist)

Updated on 1st August 2025

What is Gepretix?

Gepretix is a body-identical progesterone used in hormone replacement therapy (HRT) for individuals who still have a womb. It is made from plant sources and is chemically identical to the progesterone your body naturally produces.

When you take oestrogen as part of HRT, it can cause the lining of the womb (endometrium) to thicken. Gepretix balances this effect, helping to keep the lining healthy and reducing the risk of endometrial cancer.

Gepretix is usually prescribed alongside oestrogen in either a cyclical (monthly) or continuous (daily) regimen, depending on your stage of menopause. If you’ve had a hysterectomy, you typically won’t need it.

Why choose Gepretix?

Gepretix is part of the body-identical HRT group. That means it matches the hormones your body naturally makes and is often preferred over synthetic progestogens for several reasons:

Body-identical and plant-derived, offering a more natural option
Fewer side effects compared to synthetic progestogens
May improve sleep, particularly when taken at night
Less impact on mood, with many reporting a calming effect
Well tolerated, even among those sensitive to other forms of HRT

Gepretix may be a good option if:

You’re looking for a body-identical HRT
You’ve had mood-related side effects on synthetic progestogens
You are peri- or postmenopausal and still have your womb

Recent guidance from the British Menopause Society and NICE increasingly supports the use of body-identical options like Gepretix.

How to use Gepretix

Instructions for use

Everything you need to know to safely use Gepretix

1 Helps maintain a healthy endometrial lining

2 May support better sleep and reduced anxiety, particularly when taken at night

3 Is generally well tolerated and preferred by many for its natural profile

This page is provided for reference purposes only. Always follow the advice and guidance of your prescribing doctor regarding your medication and prescriptions. Do not make any changes to your medication regimen without consulting your healthcare provider.

Gepretix

What is Gepretix?

Why choose Gepretix?

How to use Gepretix

Benefits of Gepretix

Frequently asked questions